Eur Heart J ; 31 — Anti-inflammatory therapies for cardiovascular disease.
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To prevent training, this mechanism can be targeted, for example using inhibitors of glycolysis, or inhibitors of micro RNAs that dictate the balance between glycolysis and OXPHOS.
In vivothis trained state coincided with activated monocytes which accumulated more rapidly into the arterial wall in vivo. The epigenetic memory of monocytes and macrophages as a novel drug target in atherosclerosis.
Because monocytes and macrophages have life spans in the order of hours to days, their upstream progenitors, including bone marrow haematopoietic progenitor cells HSPCs should also be investigated.
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Curr Opin Immunol ; 29 :1—7. Cholesterol, inflammation and innate immunity. Myeloid related proteins activate toll-like receptor 4 in human acute coronary syndromes.
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